Reading-across data from one substance to another, where scientifically appropriate and documented, is a concept that is encouraged in the REACH legislation.
Many different factors must be taken into account when assessing the scientific rationale for reading-across from one substance to another,
The REACH registration technical dossiers that the Molybdenum Consortium is preparing use both substance-specific data and read-across.
Broadly speaking, physico-chemical endpoints are substance-specific, and read-across is used for many, but not all, environmental and mammalian toxicology end-points.
The MoCon 'read-across substance' is sodium molybdate. Speciation work has been conducted to demonstrate that it is scientifically appropriate to read-across from this substance to the other substances in the MoCon portfolio.
For MoCon substances, environmentally and physiologically the significant species is the MoO42- ion. All Mocon substances transform into the MoO42- ion and enter an organism as such. For this reason, the focus for the MoCon research is the molybate ion.
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